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DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores.

Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively. DNA strand scission by the antitumor antibiotic is significantly enhanced by the addition of NADPH or thiol compounds. The preferential cutting site of dynemicin is on th...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sugiura, Y, Shiraki, T, Konishi, M, Oki, T
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53997/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2339123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.10.3831
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