Esperamicins, a class of potent antitumor antibiotics: mechanism of action.

The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely potent cytotoxicity. The mechanism by which these drugs produce cytotoxicity was investigated and found to be related to the formation of single- and double-strand DNA breaks...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Long, B H, Golik, J, Forenza, S, Ward, B, Rehfuss, R, Dabrowiak, J C, Catino, J J, Musial, S T, Brookshire, K W, Doyle, T W
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286391/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2643098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.2
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