The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production

Ganciclovir (GCV) and acyclovir (ACV) are guanine nucleoside analogues that inhibit lytic herpesvirus replication. GCV and ACV must be monophosphorylated by virally encoded enzymes to be converted into nucleotides and incorporated into viral DNA. However, whether GCV and/or ACV phosphorylation in Ep...

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Bibliografski detalji
Glavni autori: Meng, Qiao, Hagemeier, Stacy R., Fingeroth, Joyce D., Gershburg, Edward, Pagano, Joseph S., Kenney, Shannon C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863746/
https://ncbi.nlm.nih.gov/pubmed/20181711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02487-09
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