The Epstein-Barr Virus Thymidine Kinase Does Not Phosphorylate Ganciclovir or Acyclovir and Demonstrates a Narrow Substrate Specificity Compared to the Herpes Simplex Virus Type 1 Thymidine Kinase

The Epstein-Barr virus (EBV) thymidine kinase (TK) was expressed in mammalian 143B TK(−) cells to investigate its substrate specificity. The herpes simplex virus type 1 (HSV-1) TK was similarly expressed for comparison. Both viral TKs conferred a TK(+) phenotype on 143B TK(−) cells. The nucleoside a...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Gustafson, Erik A., Chillemi, Antoinette C., Sage, David R., Fingeroth, Joyce D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105967/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9797227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.11.2923
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!