The Epstein-Barr Virus Thymidine Kinase Does Not Phosphorylate Ganciclovir or Acyclovir and Demonstrates a Narrow Substrate Specificity Compared to the Herpes Simplex Virus Type 1 Thymidine Kinase

The Epstein-Barr virus (EBV) thymidine kinase (TK) was expressed in mammalian 143B TK(−) cells to investigate its substrate specificity. The herpes simplex virus type 1 (HSV-1) TK was similarly expressed for comparison. Both viral TKs conferred a TK(+) phenotype on 143B TK(−) cells. The nucleoside a...

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Detaylı Bibliyografya
Asıl Yazarlar: Gustafson, Erik A., Chillemi, Antoinette C., Sage, David R., Fingeroth, Joyce D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 1998
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC105967/
https://ncbi.nlm.nih.gov/pubmed/9797227
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