The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production

Ganciclovir (GCV) and acyclovir (ACV) are guanine nucleoside analogues that inhibit lytic herpesvirus replication. GCV and ACV must be monophosphorylated by virally encoded enzymes to be converted into nucleotides and incorporated into viral DNA. However, whether GCV and/or ACV phosphorylation in Ep...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Meng, Qiao, Hagemeier, Stacy R., Fingeroth, Joyce D., Gershburg, Edward, Pagano, Joseph S., Kenney, Shannon C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863746/
https://ncbi.nlm.nih.gov/pubmed/20181711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02487-09
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