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Binding of the ClpA Unfoldase Opens the Axial Gate of ClpP Peptidase

ClpP is a serine protease whose active sites are sequestered in a cavity enclosed between two heptameric rings of subunits. The ability of ClpP to process folded protein substrates depends on its being partnered by an AAA+ ATPase/unfoldase, ClpA or ClpX. In active complexes, substrates are unfolded...

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Main Authors: Effantin, Grégory, Maurizi, Michael R., Steven, Alasdair C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863180/
https://ncbi.nlm.nih.gov/pubmed/20236930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090498
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