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A Single ClpS Monomer Is Sufficient to Direct the Activity of the ClpA Hexamer

ClpS is an adaptor protein that interacts with ClpA and promotes degradation of proteins with N-end rule degradation motifs (N-degrons) by ClpAP while blocking degradation of substrates with other motifs. Although monomeric ClpS forms a 1:1 complex with an isolated N-domain of ClpA, only one molecul...

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Detalhes bibliográficos
Main Authors: De Donatis, Gian Marco, Singh, Satyendra K., Viswanathan, Sarada, Maurizi, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838299/
https://ncbi.nlm.nih.gov/pubmed/20068042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053736
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