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Irreversible Inhibition of DNA Polymerase β by an Oxidized Abasic Lesion

[Image: see text] DNA damage is a source of carcinogenicity and is also the source of cytotoxicity of γ-radiolysis and antitumor agents, such as the enediynes. The dioxobutane lesion (DOB) is produced by a variety of DNA damaging agents, including the aforementioned. Repair of DOB is important for m...

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Bibliografske podrobnosti
Main Authors: Guan, Lirui, Greenberg, Marc M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863033/
https://ncbi.nlm.nih.gov/pubmed/20334373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja101372c
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