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DNA Interstrand Cross-link Formation by the 1,4-Dioxobutane Abasic Lesion
The oxidized abasic lesion, 5′-(2-phosphoryl-1,4-dioxobutane) (DOB) is produced concomitantly with a single strand break by a variety of DNA damaging agents that abstract a hydrogen atom from the C5'-position. Independent generation of the DOB lesion in DNA reveals that it reversibly forms inte...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784881/ https://ncbi.nlm.nih.gov/pubmed/19807122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9061695 |
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