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Scope and Mechanism of Interstrand Cross-link Formation by the C4'-Oxidized Abasic Site

The C4'-oxidized abasic site (C4-AP) is a commonly formed DNA lesion, which generates two types of interstrand cross-links (ICLs). The kinetically favored cross-link consists of two full length strands and forms reversibly and exclusively with dA. Cross-link formation is attributed to condensat...

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Detalhes bibliográficos
Main Authors: Sczepanski, Jonathan T., Jacobs, Aaron C., Majumdar, Ananya, Greenberg, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745085/
https://ncbi.nlm.nih.gov/pubmed/19722676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903404v
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