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Probing DNA interstrand cross-link formation by an oxidized abasic site using nonnative nucleotides

The C4'-oxidized abasic site (C4-AP) forms two types of interstrand cross-links with the adjacent nucleotides in DNA. Previous experiments revealed that dG does not react with the lesion and that formation of one type of cross-link is catalyzed by the opposing dA. Iso-guanosine•dC and 2-aminopu...

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Autors principals: Sczepanski, Jonathan T., Hiemstra, Christine N., Greenberg, Marc M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177026/
https://ncbi.nlm.nih.gov/pubmed/21903404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.024
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