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An Oxidized Abasic Lesion as an Intramolecular Source of DNA Adducts
5′-(2-Phosphoryl-1,4-dioxobutane) (DOB) is a lesion produced in DNA via a variety of damaging agents. The DOB lesion spontaneously generates cis- and trans-but-2-en-1,4-dial (1) via β-elimination. Cis- and trans-but-2-en-1,4-dial forms exocyclic adducts with nucleosides. We used chemically synthesiz...
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| Publicado en: | Aust J Chem |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4225716/ https://ncbi.nlm.nih.gov/pubmed/25392543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1071/CH10420 |
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