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Irreversible Inhibition of DNA Polymerase β by an Oxidized Abasic Lesion
[Image: see text] DNA damage is a source of carcinogenicity and is also the source of cytotoxicity of γ-radiolysis and antitumor agents, such as the enediynes. The dioxobutane lesion (DOB) is produced by a variety of DNA damaging agents, including the aforementioned. Repair of DOB is important for m...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863033/ https://ncbi.nlm.nih.gov/pubmed/20334373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja101372c |
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