2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride (CDDO anhydride) has been synthesized, which is the first example of an oleanane triterpenoid anhydride. CDDO anhydride shows potency similar to or higher than the corresponding acid (CDDO) in various in vitro and in vivo assays related to...

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Detalhes bibliográficos
Main Authors: Honda, Tadashi, Padegimas, Eric M., David, Emilie, Sundararajan, Chitra, Liby, Karen T., Williams, Charlotte, Sporn, Michael B., Visnick, Melean
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862379/
https://ncbi.nlm.nih.gov/pubmed/20188548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.02.007
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