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Novel Tricyclic Compounds Having Acetylene Groups at C-8a and Cyano Enones in Rings A and C: Highly Potent Anti-inflammatory and Cytoprotective Agents

Novel C-8a functionalized tricyclic compounds having cyano enones in rings A and C have been synthesized and biologically evaluated. Amongst them, compounds with acetylene groups at C-8a show extremely high potency in in vitro and in vivo bioassays for anti-inflammatory and cytoprotective activities...

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Autors principals: Honda, Tadashi, Sundararajan, Chitra, Yoshizawa, Hidenori, Su, Xiaobo, Honda, Yukiko, Liby, Karen T., Sporn, Michael B., Gribble, Gordon W.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522370/
https://ncbi.nlm.nih.gov/pubmed/17367124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070141c
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