Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A

Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-γ. Analogue 10 is highly and orally active in vivo for induction of the anti-i...

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Main Authors: Honda, Tadashi, Liby, Karen T., Su, Xiaobo, Sundararajan, Chitra, Honda, Yukiko, Suh, Nanjoo, Risingsong, Renee, Williams, Charlotte R., Royce, Darlene B., Sporn, Michael B., Gribble, Gordon W.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950140/
https://ncbi.nlm.nih.gov/pubmed/16996735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.09.012
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