Tricyclic Compounds Containing Non-enolizable Cyano Enones. A Novel Class of Highly Potent Anti-inflammatory and Cytoprotective Agents

Forty-four novel tricycles containing non-enolizable cyano enones (TCEs) were designed and synthesized on the basis of a semisynthetic pentacyclic triterpenoid, bardoxolone methyl, which is currently being developed in Phase II clinical trials for the treatment of severe chronic kidney disease in di...

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Detalhes bibliográficos
Main Authors: Honda, Tadashi, Yoshizawa, Hidenori, Sundararajan, Chitra, David, Emilie, Lajoie, Marc J., Favaloro, Frank G., Janosik, Tomasz, Su, Xiaobo, Honda, Yukiko, Roebuck, Bill D., Gribble, Gordon W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251033/
https://ncbi.nlm.nih.gov/pubmed/21361338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101445p
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