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Toward the design of mutation-resistant enzyme inhibitors: Further evaluation of the substrate envelope hypothesis
Previous studies have shown the usefulness of the substrate envelope concept in the analysis and prediction of drug resistance profiles for HIV protease mutants. This study tests its applicability to several other therapeutic targets: Abl kinase, chitinase, thymidylate synthase, dihydrofolate reduct...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860775/ https://ncbi.nlm.nih.gov/pubmed/19703025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00851.x |
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