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Biochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase (BlaC) with the Carbapenems Ertapenem and Doripenem
Despite the enormous success of β-lactams as broad-spectrum antibacterials, they have never been widely used for the treatment of TB due to intrinsic resistance that is caused by the presence of a chromosomally-encoded gene (blaC) in Mycobacterium tuberculosis. Our previous studies of TB BlaC reveal...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860635/ https://ncbi.nlm.nih.gov/pubmed/20353175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100232q |
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