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Tebipenem, a New Carbapenem Antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis

[Image: see text] The genome of Mycobacterium tuberculosis contains a gene, blaC, which encodes a highly active β-lactamase (BlaC). We have previously shown that BlaC has an extremely broad spectrum of activity against penicillins and cephalosporins but weak activity against newer carbapenems. We ha...

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Detalhes bibliográficos
Main Authors: Hazra, Saugata, Xu, Hua, Blanchard, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053071/
https://ncbi.nlm.nih.gov/pubmed/24846409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500339j
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