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NXL104 Irreversibly Inhibits the β-Lactamase from Mycobacterium tuberculosis ()
cNXL104 is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Our kinetic and mass spectrometric analysis demonstrates that NXL104 quantitatively inhibits BlaC, the only chromosomally encoded β-lactamase from Mycobacterium tuberculosis, by forming a carbamyl adduct with the enzyme....
में बचाया:
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448018/ https://ncbi.nlm.nih.gov/pubmed/22587688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300508r |
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