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Biochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase (BlaC) with the Carbapenems Ertapenem and Doripenem

Despite the enormous success of β-lactams as broad-spectrum antibacterials, they have never been widely used for the treatment of TB due to intrinsic resistance that is caused by the presence of a chromosomally-encoded gene (blaC) in Mycobacterium tuberculosis. Our previous studies of TB BlaC reveal...

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Sonraí Bibleagrafaíochta
Main Authors: Tremblay, Lee W., Fan, Fan, Blanchard, John S
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860635/
https://ncbi.nlm.nih.gov/pubmed/20353175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100232q
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