Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of β-Lactam–β-Lactamase Inhibitor Combinations

The current emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for novel treatment strategies. Recently, BlaC, the principal β-lactamase of Mycobacterium tuberculosis, was recognized as a potential therapeutic target. The combination of meropenem and clavu...

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Bibliografski detalji
Glavni autori: Kurz, Sebastian G., Wolff, Kerstin A., Hazra, Saugata, Bethel, Christopher R., Hujer, Andrea M., Smith, Kerri M., Xu, Yan, Tremblay, Lee W., Blanchard, John S., Nguyen, Liem, Bonomo, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Mechanisms of Resistance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837893/
https://ncbi.nlm.nih.gov/pubmed/24060876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01253-13
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