Hydrolysis of Clavulanate by Mycobacterium tuberculosis β-Lactamase BlaC Harboring a Canonical SDN Motif

Combinations of β-lactams with clavulanate are currently being investigated for tuberculosis treatment. Since Mycobacterium tuberculosis produces a broad spectrum β-lactamase, BlaC, the success of this approach could be compromised by the emergence of clavulanate-resistant variants, as observed for...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Soroka, Daria, Li de la Sierra-Gallay, Inès, Dubée, Vincent, Triboulet, Sébastien, van Tilbeurgh, Herman, Compain, Fabrice, Ballell, Lluis, Barros, David, Mainardi, Jean-Luc, Hugonnet, Jean-Emmanuel, Arthur, Michel
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538473/
https://ncbi.nlm.nih.gov/pubmed/26149997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00598-15
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