Activation of cAMP-dependent Signaling Induces Oxidative Modification of the Cardiac Na(+)-K(+) Pump and Inhibits Its Activity

Cellular signaling can inhibit the membrane Na(+)-K(+) pump via protein kinase C (PKC)-dependent activation of NADPH oxidase and a downstream oxidative modification, glutathionylation, of the β(1) subunit of the pump α/β heterodimer. It is firmly established that cAMP-dependent signaling also regula...

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Autores principales: White, Caroline N., Liu, Chia-Chi, Garcia, Alvaro, Hamilton, Elisha J., Chia, Karin K. M., Figtree, Gemma A., Rasmussen, Helge H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859534/
https://ncbi.nlm.nih.gov/pubmed/20194511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090225
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