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Activation of cAMP-dependent Signaling Induces Oxidative Modification of the Cardiac Na(+)-K(+) Pump and Inhibits Its Activity
Cellular signaling can inhibit the membrane Na(+)-K(+) pump via protein kinase C (PKC)-dependent activation of NADPH oxidase and a downstream oxidative modification, glutathionylation, of the β(1) subunit of the pump α/β heterodimer. It is firmly established that cAMP-dependent signaling also regula...
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Autori principali: | , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859534/ https://ncbi.nlm.nih.gov/pubmed/20194511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090225 |
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