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Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina

Functional inactivation of the Retinoblastoma (pRB) pathway is an early and obligatory event in tumorigenesis. The importance of pRB is usually explained by its ability to promote cell cycle exit. Here, we demonstrate that, independently of cell cycle exit control, in cooperation with the Hippo tumo...

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מידע ביבליוגרפי
Main Authors: Nicolay, Brandon N., Bayarmagnai, Battuya, Moon, Nam Sung, Benevolenskaya, Elizaveta V., Frolov, Maxim V.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858677/
https://ncbi.nlm.nih.gov/pubmed/20421993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000918
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