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The archipelago tumor suppressor gene limits Rb/E2F-regulated apoptosis in developing Drosophila tissues
BACKGROUND: The Drosophila archipelago gene (ago) encodes the specificity component of a ubiquitin-ligase that targets the Cyclin E and dMyc proteins for degradation. Its human ortholog Fbw7 is commonly lost in many cancers, suggesting that failure to degrade ago/Fbw7 targets leads to excess tissue...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2755617/ https://ncbi.nlm.nih.gov/pubmed/19733076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.07.068 |
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