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Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye

archipelago (ago)/Fbw7 encodes a conserved protein that functions as the substrate-receptor component of a polyubiquitin ligase that suppresses tissue growth in flies and tumorigenesis in vertebrates. Ago/Fbw7 targets multiple proteins for degradation, including the G1-S regulator Cyclin E and the o...

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Bibliografske podrobnosti
Main Authors: Nicholson, Sarah C., Nicolay, Brandon N., Frolov, Maxim V., Moberg, Kenneth H.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005602/
https://ncbi.nlm.nih.gov/pubmed/21148181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.054429
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