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Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye
archipelago (ago)/Fbw7 encodes a conserved protein that functions as the substrate-receptor component of a polyubiquitin ligase that suppresses tissue growth in flies and tumorigenesis in vertebrates. Ago/Fbw7 targets multiple proteins for degradation, including the G1-S regulator Cyclin E and the o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005602/ https://ncbi.nlm.nih.gov/pubmed/21148181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.054429 |
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