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Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
The Hippo signaling pathway regulates organ size and tissue homeostasis from Drosophila to mammals. Central to this pathway is a kinase cascade wherein Hippo (Hpo), in complex with Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki)...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858562/ https://ncbi.nlm.nih.gov/pubmed/20159598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.12.012 |
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