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Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

The Hippo signaling pathway regulates organ size and tissue homeostasis from Drosophila to mammals. Central to this pathway is a kinase cascade wherein Hippo (Hpo), in complex with Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yu, Jianzhong, Zheng, Yonggang, Dong, Jixin, Klusza, Stephen, Deng, Wu-Min, Pan, Duojia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858562/
https://ncbi.nlm.nih.gov/pubmed/20159598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.12.012
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