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The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

The conserved Hippo signaling pathway regulates organ size in both Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of th...

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Detalhes bibliográficos
Main Authors: Zhang, Nailing, Bai, Haibo, David, Karen K., Dong, Jixin, Zheng, Yonggang, Cai, Jing, Giovannini, Marco, Liu, Pentao, Anders, Robert A., Pan, Duojia
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925178/
https://ncbi.nlm.nih.gov/pubmed/20643348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.06.015
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