The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

The conserved Hippo signaling pathway regulates organ size in both Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of th...

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Main Authors: Zhang, Nailing, Bai, Haibo, David, Karen K., Dong, Jixin, Zheng, Yonggang, Cai, Jing, Giovannini, Marco, Liu, Pentao, Anders, Robert A., Pan, Duojia
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925178/
https://ncbi.nlm.nih.gov/pubmed/20643348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.06.015
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