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Rac1 targeting suppresses p53 deficiency–mediated lymphomagenesis

Mutation of the p53 tumor suppressor is associated with disease progression, therapeutic resistance, and poor prognosis in patients with lymphoid malignancies and can occur in approximately 50% of Burkitt lymphomas. Thus, new therapies are needed to specifically target p53-deficient lymphomas with i...

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Bibliografiske detaljer
Main Authors: Bosco, Emily E., Ni, Wenjun, Wang, Lei, Guo, Fukun, Johnson, James F., Zheng, Yi
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858481/
https://ncbi.nlm.nih.gov/pubmed/20179179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-202440
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