RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

Neoplastic transformation is driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiproliferative signals. These oncogenic DNA lesions, acquired through errors in DNA replication, gene recombination, or extrinsically imposed damage, are thought to activate mult...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Delbridge, Alex R.D., Pang, Swee Heng Milon, Vandenberg, Cassandra J., Grabow, Stephanie, Aubrey, Brandon J., Tai, Lin, Herold, Marco J., Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030795/
https://ncbi.nlm.nih.gov/pubmed/27621418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150477
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