RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

Neoplastic transformation is driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiproliferative signals. These oncogenic DNA lesions, acquired through errors in DNA replication, gene recombination, or extrinsically imposed damage, are thought to activate mult...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Exp Med
Autores principales: Delbridge, Alex R.D., Pang, Swee Heng Milon, Vandenberg, Cassandra J., Grabow, Stephanie, Aubrey, Brandon J., Tai, Lin, Herold, Marco J., Strasser, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030795/
https://ncbi.nlm.nih.gov/pubmed/27621418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150477
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares