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RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice
Neoplastic transformation is driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiproliferative signals. These oncogenic DNA lesions, acquired through errors in DNA replication, gene recombination, or extrinsically imposed damage, are thought to activate mult...
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| Veröffentlicht in: | J Exp Med |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030795/ https://ncbi.nlm.nih.gov/pubmed/27621418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150477 |
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