Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Although tumor development requires impaired apoptosis, we describe a novel paradigm of apoptosis-dependent tumorigenesis. Because DNA damage triggers apoptosis through p53-mediated induction of BH3-only proteins Puma and Noxa, we explored their roles in γ-radiation-induced thymic lymphomagenesis. S...

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Detalhes bibliográficos
Main Authors: Michalak, Ewa M., Vandenberg, Cassandra J., Delbridge, Alex R.D., Wu, Li, Scott, Clare L., Adams, Jerry M., Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912558/
https://ncbi.nlm.nih.gov/pubmed/20679396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1940110
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