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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
Evasion of apoptosis contributes importantly to c-Myc-induced tumorigenesis. The BH3-only Bcl-2 family members Puma and Noxa are critical pro-apoptotic transcriptional targets of p53, a major mediator of Myc-induced apoptosis and suppressor of Myc-induced tumorigenesis. Hence, we have explored the i...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743939/ https://ncbi.nlm.nih.gov/pubmed/19148184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.195 |
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