Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

Evasion of apoptosis contributes importantly to c-Myc-induced tumorigenesis. The BH3-only Bcl-2 family members Puma and Noxa are critical pro-apoptotic transcriptional targets of p53, a major mediator of Myc-induced apoptosis and suppressor of Myc-induced tumorigenesis. Hence, we have explored the i...

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Bibliographic Details
Main Authors: Michalak, EM, Jansen, ES, Happo, L, Cragg, MS, Tai, L, Smyth, GK, Strasser, A, Adams, JM, Scott, CL
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743939/
https://ncbi.nlm.nih.gov/pubmed/19148184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.195
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