Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

DNA-damaging chemotherapy is the backbone of cancer treatment, although it is not clear how such treatments kill tumor cells. In nontransformed lymphoid cells, the combined loss of 2 proapoptotic p53 target genes, Puma and Noxa, induces as much resistance to DNA damage as loss of p53 itself. In Eμ-M...

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Detalhes bibliográficos
Main Authors: Happo, Lina, Cragg, Mark S., Phipson, Belinda, Haga, Jon M., Jansen, Elisa S., Herold, Marco J., Dewson, Grant, Michalak, Ewa M., Vandenberg, Cassandra J., Smyth, Gordon K., Strasser, Andreas, Cory, Suzanne, Scott, Clare L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012543/
https://ncbi.nlm.nih.gov/pubmed/20829369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-280818
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