DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

Trp63, a transcription factor related to the tumor suppressor p53, is activated by diverse stimuli and can initiate a range of cellular responses. TAp63 is the predominant Trp53 family member in primordial follicle oocytes and essential for their apoptosis triggered by DNA damage in vivo. Following...

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Main Authors: Kerr, Jeffrey B., Hutt, Karla J., Michalak, Ewa M., Cook, Michele, Vandenberg, Cassandra J., Liew, Seng H., Bouillet, Philippe, Mills, Alea, Scott, Clare L., Findlay, Jock K., Strasser, Andreas
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496022/
https://ncbi.nlm.nih.gov/pubmed/23000175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.017
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