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DNA repair in primordial follicle oocytes following cisplatin treatment

PURPOSE: Genotoxic chemotherapy and radiotherapy can cause DNA double stranded breaks (DSBs) in primordial follicle (PMF) oocytes, which then undergo apoptosis. The development of effective new fertility preservation agents has been hampered, in part, by a limited understanding of DNA repair in PMF...

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Detalhes bibliográficos
Publicado no:J Assist Reprod Genet
Main Authors: Nguyen, Quynh-Nhu, Zerafa, Nadeen, Findlay, Jock K., Hickey, Martha, Hutt, Karla J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266985/
https://ncbi.nlm.nih.gov/pubmed/33864208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-021-02184-3
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