Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Female gametes are stored in the ovary in structures called primordial follicles, the supply of which is non-renewable. It is well established that DNA-damaging cancer treatments can deplete the ovarian reserve of primordial follicles, causing premature ovarian failure and infertility. The precise m...

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Publicado no:Cell Death Dis
Main Authors: Nguyen, Quynh-Nhu, Zerafa, Nadeen, Liew, Seng H., Morgan, F. Hamish, Strasser, Andreas, Scott, Clare L., Findlay, Jock K., Hickey, Martha, Hutt, Karla J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966424/
https://ncbi.nlm.nih.gov/pubmed/29795269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0633-7
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