A small molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo

The BCL6 transcriptional repressor is the most frequently involved oncogene in diffuse large B cell lymphoma (DLBCL). We combined computer-aided drug design with functional assays to identify low molecular weight compounds that bind to the corepressor binding groove of the BCL6 BTB domain. One such...

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Bibliografiset tiedot
Päätekijät: Cerchietti, Leandro C., Ghetu, Alexandru F., Zhu, Xiao, Da Silva, Gustavo F., Shijun, Zhong, Matthews, Marilyn, Bunting, Karen L., Polo, Jose M., Farès, Christophe, Arrowsmith, Cheryl H., Yang, Shao Ning, Garcia, Monica, Coop, Andrew, MacKerell, Alexander D., Privé, Gilbert G., Melnick, Ari
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858395/
https://ncbi.nlm.nih.gov/pubmed/20385364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.12.050
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