A small molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo

The BCL6 transcriptional repressor is the most frequently involved oncogene in diffuse large B cell lymphoma (DLBCL). We combined computer-aided drug design with functional assays to identify low molecular weight compounds that bind to the corepressor binding groove of the BCL6 BTB domain. One such...

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Autors principals: Cerchietti, Leandro C., Ghetu, Alexandru F., Zhu, Xiao, Da Silva, Gustavo F., Shijun, Zhong, Matthews, Marilyn, Bunting, Karen L., Polo, Jose M., Farès, Christophe, Arrowsmith, Cheryl H., Yang, Shao Ning, Garcia, Monica, Coop, Andrew, MacKerell, Alexander D., Privé, Gilbert G., Melnick, Ari
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858395/
https://ncbi.nlm.nih.gov/pubmed/20385364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.12.050
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