A Novel Fibroblast Growth Factor-1 (FGF1) Mutant that Acts as an FGF Antagonist

BACKGROUND: Crosstalk between integrins and FGF receptors has been implicated in FGF signaling, but the specifics of the crosstalk are unclear. We recently discovered that 1) FGF1 directly binds to integrin αvβ3, 2) the integrin-binding site and FGF receptor (FGFR) binding site are distinct, and 3)...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yamaji, Satoshi, Saegusa, Jun, Ieguchi, Katsuaki, Fujita, Masaaki, Mori, Seiji, Takada, Yoko K., Takada, Yoshikazu
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858075/
https://ncbi.nlm.nih.gov/pubmed/20422052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010273
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