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Integrins αvβ3 and α4β1 act as co-receptors for fractalkine and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1
The membrane-bound chemokine fractalkine (FKN, CX3CL1) on endothelial cells plays a role in leukocyte trafficking. The chemokine domain (FKN-CD) is sufficient for inducing FKN signaling (e.g., integrin activation) and FKN-CD binds to its receptor CX3CR1 on leukocytes. While previous studies suggest...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518660/ https://ncbi.nlm.nih.gov/pubmed/23125415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200889 |
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