Proinflammatory Secreted Phospholipase A2 Type IIA (sPLA-IIA) Induces Integrin Activation through Direct Binding to a Newly Identified Binding Site (Site 2) in Integrins αvβ3, α4β1, and α5β1

Integrins are activated by signaling from inside the cell (inside-out signaling) through global conformational changes of integrins. We recently discovered that fractalkine activates integrins in the absence of CX3CR1 through the direct binding of fractalkine to a ligand-binding site in the integrin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fujita, Masaaki, Zhu, Kan, Fujita, Chitose K., Zhao, Min, Lam, Kit S., Kurth, Mark J., Takada, Yoko K., Takada, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281730/
https://ncbi.nlm.nih.gov/pubmed/25398877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.579946
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