Soluble CD40L activates soluble and cell-surface integrin αvβ3, α5β1, and α4β1 by binding to the allosteric ligand-binding site (site 2)

CD40L is a member of the TNF superfamily that participates in immune cell activation. It binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the trimeric interface of CD40L. We previously showed that several integrin ligands can bind to the allosteric site (site 2)...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Takada, Yoko K., Shimoda, Michiko, Maverakis, Emanual, Felding, Brunie H., Cheng, R. Holland, Takada, Yoshikazu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960543/
https://ncbi.nlm.nih.gov/pubmed/33571526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100399
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