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Identification of Inhibitors against Interaction between Pro-inflammatory sPLA2-IIA Protein and Integrin αvβ3
Increased concentrations of secreted phospholipase A2 type IIA (sPLA2-IIA), have been found in the synovial fluid of patients with rheumatoid arthritis. It has been shown that sPLA2-IIA specifically binds to integrin αvβ3, and initiates a signaling pathway that leads to cell proliferation and inflam...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570851/ https://ncbi.nlm.nih.gov/pubmed/23164706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.10.080 |
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