Identification of Inhibitors against Interaction between Pro-inflammatory sPLA2-IIA Protein and Integrin αvβ3

Increased concentrations of secreted phospholipase A2 type IIA (sPLA2-IIA), have been found in the synovial fluid of patients with rheumatoid arthritis. It has been shown that sPLA2-IIA specifically binds to integrin αvβ3, and initiates a signaling pathway that leads to cell proliferation and inflam...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Ye, Long, Dickerson, Tiffany, Kaur, Handeep, Takada, Yoko K., Fujita, Masaaki, Liu, Ruiwu, Knapp, John M., Lam, Kit S., Schore, Neil E., Kurth, Mark J., Takada, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570851/
https://ncbi.nlm.nih.gov/pubmed/23164706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.10.080
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