Pro-inflammatory Secretory Phospholipase A2 Type IIA Binds to Integrins αvβ3 and α4β1 and Induces Proliferation of Monocytic Cells in an Integrin-dependent Manner

Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA ind...

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Hlavní autoři: Saegusa, Jun, Akakura, Nobuaki, Wu, Chun-Yi, Hoogland, Case, Ma, Zi, Lam, Kit S., Liu, Fu-Tong, Takada, Yoko K., Takada, Yoshikazu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Genomics, Proteomics, and Bioinformatics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533795/
https://ncbi.nlm.nih.gov/pubmed/18635536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804835200
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