The Direct Binding of Insulin-like Growth Factor-1 (IGF-1) to Integrin αvβ3 Is Involved in IGF-1 Signaling

It has been proposed that ligand occupancy of integrin αvβ3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of αvβ3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free...

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Detalhes bibliográficos
Main Authors: Saegusa, Jun, Yamaji, Satoshi, Ieguchi, Katsuaki, Wu, Chun-Yi, Lam, Kit S., Liu, Fu-Tong, Takada, Yoko K., Takada, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782004/
https://ncbi.nlm.nih.gov/pubmed/19578119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013201
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